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Klow blend
Klow blend

KLOW Peptide Blend

$99.99 $89.95

Glow Peptide Blend – Over 99% pure lab tested blend of GHK-Cu, TB-500, and BPC-157

“GLOW” GHK-Cu | TB-500 | BPC-157
Appearance: Blue lyophilized powder
Storage: 2-8°C
Purity: ≥99%

BULK QUANTITY DISCOUNT:

2-4 vials – 5% OFF

5-9 vials – 10% OFF

10-14 vials – 12% OFF

15-20 vials – 15% OFF

SKU: GLOW-1 Categories: , Tags: , , , Brand:

Description

 

Klow peptide blend for sale

KLOW Peptide Blend

Mechanism of action and evidence summary with links to PubMed/PMC. Educational only—no medical advice or therapeutic claims.

GHK-Cu
CAS NO: 49557-75-7
Molecular Formula: C14H24N6O4
Molecular Weight: 340.39

TB-500 (TB-4) 43 amino acid chain
CAS NO: 77591-33-4
Molecular Formula: C212H350N56O78S
Molecular Weight: 4963 g/mol

BPC-157
CAS NO: 137525-51-0
Molecular Formula: C62H98N16O22
Molecular Weight: 1419.54

Overview & Positioning

KLOW denotes a research-oriented combination of four peptides: BPC-157, TB-500 (a thymosin-beta-4–based agent), GHK-Cu (glycyl-L-histidyl-L-lysine copper complex), and KPV (Lys-Pro-Val; an α-MSH–derived tripeptide). Peer-reviewed literature primarily investigates each component individually; comprehensive studies on the four-peptide blend are limited. The sections below summarize reported mechanisms and representative studies.

Mechanism of Action — Component Detail

BPC-157 (pentadecapeptide)

  • Angiogenic signaling (VEGFR2 → Akt → eNOS): Endothelial and ischemia models report VEGFR2 involvement with downstream Akt/eNOS activation and tube formation. PubMed 27847966
  • NO-dependent vasomotor modulation: Isolated aorta experiments describe nitric-oxide–linked effects on vascular tone and Src/Caveolin-1/eNOS interactions. PMC7555539
  • Tendon-cell signaling: Increased growth-hormone receptor expression and enhanced GH-evoked JAK2 activation reported in tendon fibroblasts. PMC6271067
  • Contextual reviews: Described within cytoprotection/adaptive cytoprotection frameworks. PMC7096228

TB-500 / Thymosin-β4 (Tβ4)

“TB-500” is commonly used in research contexts for Tβ4-based materials; citations reference Tβ4 in the scientific literature.

BPC-157 • TB-500/Tβ4 • GHK-Cu • KPV

  • Actin dynamics & cell migration: Tβ4 binds G-actin (LKKTETQ motif), associated with endothelial/keratinocyte migration and tubule formation. PubMed 14500546
  • PI3K/Akt/eNOS axis & EPC function: Studies in endothelial-progenitor cells report Akt/eNOS activation and improved tube formation under stress. PMC6143828; PubMed 29956769
  • Epithelial repair models: Corneal and dermal wound models describe enhanced re-epithelialization and migration. PMC2701135; PubMed 11950239

GHK-Cu (glycyl-histidyl-lysine:copper)

  • ECM remodeling: Low-nanomolar stimulation of collagen and glycosaminoglycan synthesis; modulation of MMP/TIMP balance. PubMed 3169264; PubMed 11045606
  • Gene-program regulation: Transcriptomic work reports shifts toward repair-associated signatures and antioxidant pathways. PMC5332963; PMC4508379
  • Inflammation/oxidative stress models: Preclinical studies describe modulation of TGF-β/Smad and NF-κB-related signaling in injury contexts. PubMed 31809714

KPV (Lys-Pro-Val; α-MSH–derived tripeptide)

  • NF-κB pathway modulation: KPV has been reported to reduce NF-κB activation/nuclear translocation in epithelial models. PubMed 11256945
  • PepT1-mediated epithelial uptake: In colitis models, uptake through di/tripeptide transporter PepT1—upregulated during inflammation—has been implicated in local activity. PMC2431115
  • Melanocortin-receptor context: Some effects appear partially independent of MC1R; airway epithelium work implicates MC3R-linked signaling. PMC3403564; PubMed 18092346

Mechanistic Complementarity (Blend Rationale)

Viewed as a research hypothesis, the four components cover complementary biological nodes:

  • Endothelial dynamics & perfusion: BPC-157 (VEGFR2→Akt→eNOS; NO homeostasis) and Tβ4 (actin-guided migration; PI3K/Akt/eNOS) address vascular signaling and cell motility.
  • Matrix remodeling & structure: GHK-Cu is associated with collagen/GAG synthesis and MMP/TIMP balance; Tβ4 supports cytoskeletal organization and epithelial migration.
  • Inflammatory set-point & mucosal interface: KPV engages NF-κB-related pathways and PepT1-mediated epithelial uptake; BPC-157 is discussed in cytoprotection contexts.

These intersections are hypothesis-generating based on component data; they do not establish blend-level outcomes.

Evidence Snapshot (preclinical/early)

Important: Most available studies are preclinical (cell/animal) or context-specific. Human data are limited. Readers should evaluate the original methods and endpoints in the linked articles.

Selected PubMed / PMC References

    1. Hsieh MJ, et al. VEGFR2→Akt→eNOS signaling with BPC-157. PubMed 27847966
    2. Hsieh MJ, et al. NO-dependent vasomotor modulation by BPC-157. PMC7555539
    3. Chang CH, et al. GHR up-regulation & JAK2 activation in tendon fibroblasts. PMC6271067
    4. Sikiric P, et al. Cytoprotection/adaptive cytoprotection review. PMC7096228

    1. Philp D, et al. Actin-binding motif & angiogenesis. PubMed 14500546
    2. Sosne G, et al. Corneal repair & anti-inflammatory actions. PMC2701135
    3. Qiu F, et al. EPC function via Akt/eNOS with Tβ4. PMC6143828
    4. Zhao Y, et al. VEGF expression & EPC paracrine effects. PubMed 29956769

    1. Maquart FX, et al. Collagen synthesis stimulated by GHK-Cu. PubMed 3169264
    2. Siméon A, et al. ECM/MMP-2 modulation by GHK-Cu. PubMed 11045606
    3. Pickart L, et al. GHK-Cu as gene-program modulator (reviews/data). PMC4508379; PMC5332963
    4. Ma W, et al. TGF-β/Smad & oxidative-stress model. PubMed 31809714

  1. Dalmasso G, et al. PepT1-mediated uptake & colitis models. PMC2431115
  2. O’Reilly PJ, et al. Airway epithelium; MC3R/NF-κB context. PMC3403564
  3. Kannengiesser K, et al. Colitis model; MC1R-independent aspects. PubMed 18092346
  4. Haddad JJ, et al. NF-κB nuclear translocation inhibition. PubMed 11256945
Disclaimer: This page is for informational and educational purposes only. It summarizes mechanisms and research findings without making direct claims of therapeutic benefit or providing medical advice. Research peptides may not be approved for human use; consult original publications and applicable regulations.
© KLOW Research Overview
PLEASE NOTE THAT ALL PRODUCTS FEATURED HERE ARE INTENDED EXCLUSIVELY FOR RESEARCH AND DEVELOPMENT PURPOSES. THEY ARE NOT DESIGNED FOR ANY FORM OF HUMAN CONSUMPTION. THESE PRODUCTS HAVE NOT UNDERGONE EVALUATION BY THE U.S. FOOD AND DRUG ADMINISTRATION.

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