MOTS-c 10mg

Description

MOTS‑c is a mitochondria‑derived peptide consisting of 16 amino acids encoded within a short open reading frame of the mitochondrial 12S rRNA gene. Unlike nuclear‑encoded peptides, MOTS‑c is translated in the cytoplasm and can shuttle to the nucleus in response to stress or exercise signals. There it modulates transcriptional programmes via the folate–AICAR–AMPK pathway—by inhibiting the folate cycle and de novo purine synthesis, it elevates AICAR levels and activates AMPK, a key energy sensor. Studies in mice show that this signalling improves insulin sensitivity and prevents high‑fat‑diet‑induced insulin resistance and obesity. PLEASE NOTE THAT ALL PRODUCTS FEATURED HERE ARE INTENDED EXCLUSIVELY FOR RESEARCH AND DEVELOPMENT PURPOSES. THEY ARE NOT DESIGNED FOR ANY FORM OF HUMAN CONSUMPTION. THESE PRODUCTS HAVE NOT UNDERGONE EVALUATION BY THE U.S. FOOD AND DRUG ADMINISTRATION.

Beyond glucose homeostasis, MOTS‑c influences lipid metabolism. It lowers sphingolipid metabolites and raises angiopoietin‑like 4 levels, which suppresses lipoprotein lipase activity and promotes efficient β‑oxidation of fatty acids. The peptide also induces browning of white adipose tissue and up‑regulates thermogenic genes such as PGC‑1α and UCP1, potentially increasing energy expenditure. These combined actions suggest that MOTS‑c helps cells adapt to metabolic stress by enhancing fatty‑acid oxidation, improving insulin sensitivity and maintaining energy balance. Because its expression declines with age and it modulates inflammatory and mitochondrial stress responses, MOTS‑c is being investigated as a therapeutic candidate for metabolic disorders, aging‑related decline and other conditions linked to energy dysregulation.

Mechanism of action: MOTS-c’s precise action is complex, but it is understood to play a crucial role in cellular energy metabolism, including fatty acid oxidation, insulin sensitivity, and metabolic regulation. It appears to have a protective effect against metabolic stressors, contributing to the body’s adaptability to metabolic challenges.