SLU-PP-332 peptide for sale

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What is SLU-PP-332 for sale?

SLU-PP-332ย is aย synthetic pan-agonistย of the estrogen-related receptors (ERRฮฑ/ฮฒ/ฮณ), nuclear receptors that control programs for oxidative metabolism, mitochondrial function, and energy homeostasis. Published work characterizes SLU-PP-332 as a chemical tool with in vivo activity suitable for modeling exercise-responsive transcriptional programs in preclinical systems.

ss 332 peptide Mechanism of Action (scientific detail)

1) Direct activation of ERRs (ฮฑ/ฮฒ/ฮณ)

SLU-PP-332 binds ERR ligand-binding domains andย activates ERR-dependent transcription, with highest potency toward ERRฮฑ. This receptor family coordinates genes for mitochondrial respiration, lipid handling, and oxidative muscle phenotypes. In cells, SLU-PP-332 increases markers ofย mitochondrial functionย andย cellular respirationย (e.g., Seahorse assays measuring OXPHOS capacity).1

2) Exercise-like acute gene program

In mouse skeletal muscle, short-term dosing induces anย acute aerobic exercise gene signatureย (RNA-seq), including transient up-regulation ofย DDIT4ย and other ERR targets. This transcriptional response overlaps with gene sets observed after acute endurance exercise in rodents and humans, mapping SLU-PP-332 to anย exercise-mimeticย transcriptional space (mechanistic context, not a clinical claim).

3) Mitochondrial & substrate-use remodeling of slu pp 332 for sale

Preclinical data show increased oxidative enzyme content (OXPHOS complexes), higher mitochondrial markers (e.g., cytochrome c), and aย shift toward oxidative type IIa fibersย in skeletal muscle after dosing. ERR activation is a known upstream driver ofย fatty-acid oxidation,ย mitochondrial biogenesisย (PGC-1ฮฑโ€“linked coactivation), and improvedย oxidative capacityย at the tissue level.1

4) Whole-body metabolic programming (preclinical)

In diet-induced obesity and metabolic-syndrome models, pharmacologic ERR activation by SLU-PP-332 has been reported toย remodel metabolic gene networksย in multiple tissues (e.g., muscle, liver) and align physiological readouts with increased energy expenditure and lipid utilizationโ€”findings specific to theย researchย setting.2

Evidence Snapshot (preclinical)

Important:ย The studies summarized below areย preclinicalย (cell/animal). They are hypothesis-generating andย do notย establish human efficacy or safety.
  • ERR-dependent exercise program & performance (mice):ย SLU-PP-332 increased mitochondrial function in myocytes, shifted muscle toward oxidative type IIa fibers, and enhanced running endurance; ERRฮฑ dependence was demonstrated via genetic models.1
  • Metabolic-syndrome context (mice):ย ERR agonism with SLU-PP-332 aligned with improved oxidative metabolism and transcriptomic remodeling in metabolic tissues in vivo (mechanistic endpoints, not clinical outcomes).2

PubMed References (1โ€“2) of slu-pp-332 peptide for sale

  1. Billon C,ย etย al.ย Synthetic ERRฮฑ/ฮฒ/ฮณ Agonist Induces an ERRฮฑ-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.
    PubMed 36988910
  2. Billon C,ย etย al.ย A Synthetic ERR Agonist Alleviates Metabolic Syndrome.
    PubMed 37739806
Disclaimer:ย This page is forย research and educational purposes only. It does not provide medical advice, diagnosis, or treatment, and makes no direct claims of therapeutic benefit. Compounds discussed may not be approved for human use. Readers should consult the original publications and applicable regulations.
ยฉย SLU-PP-332 Research Summary