SLU-PP-332: Clinical & Research Findings on Metabolic Activity and Longevity-Relevant Pathways
SLU-PP-332 is a synthetic estrogen-related receptor (ERR) agonist investigated as an
exercise-mimetic. In mouse models of metabolic disease, ERR activation by SLU-PP-332 increases
resting energy expenditure, raises fatty acid oxidation, and reduces adiposityโmechanisms that intersect with
longevity-relevant resilience pathways. Human clinical efficacy data are not yet established.
For laboratory procurement and specifications, visit the product page:
SLU-PP-332 (Research Use Only).
Mechanism (Research Context)
- ERR Agonism: Pharmacologic activation of ERRs promotes mitochondrial programs and oxidative metabolism in skeletal muscle.
- Fuel Shift: In vivo studies report a lower respiratory exchange ratio and a shift toward lipid oxidation, consistent with exercise-like adaptation.1
- Energy Expenditure: Increased resting energy expenditure without increased locomotor activity in mice.1
Evidence Snapshot
| Domain | Key Findings | Evidence Type |
|---|---|---|
| Metabolic Activity | โ Resting energy expenditure; โ fatty acid oxidation; โ carbohydrate utilization; reduced adiposity in obese models. | Mouse metabolic syndrome models (indirect calorimetry).1 |
| Liver & Adipose | Reduced hepatic triglycerides and steatosis; decreased adipocyte size under high-fat diet conditions. | Histology/biochemical assays in DIO and ob/ob mice.1 |
| Longevity Relevance | Exercise-mimetic ERR signaling aligns with pathways tied to metabolic resilience and healthy aging (mitochondrial function, lipid utilization). | Preclinical inference from mechanistic data; direct lifespan data not yet established.1 |
Study Design Notes (Research-Only)
- Models: Diet-induced obesity and ob/ob mice at thermoneutrality were used in key studies.
- Readouts: Indirect calorimetry (RER, EE), tissue triglycerides, adipocyte histology, glucose/insulin tolerance.
- Translation: Findings are preliminary and preclinical; no approved clinical indication.
References (max 2)
- Billon C, etย al. A Synthetic ERR Agonist Alleviates Metabolic Syndrome. 2024.
Open-access summary of SLU-PP-332 effects on energy expenditure, fuel selection, adiposity, and hepatic steatosis in mouse models.
Article. - PubChem. SLU-PP-332 | C18H14N2O2 (CID 5338394). Chemical identity, synonyms, and properties.
Entry.
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Pure Tested Peptides supplies compounds strictly for laboratory research use only.
All content above is for scientific and educational purposes. These products are not medicines,
not for human consumption, and have not been evaluated or approved by the FDA to diagnose, treat, cure,
or prevent any disease.
