Description
GPR54โalso known as KISS1 receptor (KISS1R)โis a Gโproteinโcoupled receptor that serves as the endogenous target for kissPep peptides. Genetic studies have shown that kissPep10mg are the natural ligands for GPR54; lossโofโfunction mutations in GPR54 cause sexual immaturity and infertility in humans and mice.
The KISS1 gene encodes a 54โaminoโacid peptide (often called kissPEP54 or metastin), but shorter Cโterminal fragments such as kissPEPโ10, โ13 and โ14 retain full biological activity. In fact, the 10โaminoโacid Cโterminal fragment is as potent as the fullโlength peptide in stimulating the GPR54 receptor and in triggering luteinizingโhormone secretion.
KissPEP10mg Peptide has been studied and researched regarding sex drive etc in animals
1. Master Regulator of Reproductive Hormones & Puberty
KissP10 activates GnRH neurons via the GPR54 receptor, triggering luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release. Itโs a critical gatekeeper for puberty and fertility in humans and animals.
PubMed 20672907 [oai_citation:0โกPubMed](https://pubmed.ncbi.nlm.nih.gov/20672907/?utm_source=chatgpt.com)
PubMed 15500545 [oai_citation:1โกPubMed](https://pubmed.ncbi.nlm.nih.gov/15500545/?utm_source=chatgpt.com))
2. Promising Therapeutics for Fertility & Reproductive Disorders
Kissp receptor agonists show therapeutic potential for treating female reproductive disorders and infertility by stimulating physiological gonadotropin release.
PubMed 33196464 [oai_citation:3โกPubMed](https://pubmed.ncbi.nlm.nih.gov/33196464/?utm_source=chatgpt.com)
Kissp analogs may offer safer alternatives for inducing ovulation and reducing ovarian hyperstimulation risks in IVF.
MDPI review 2025 [oai_citation:4โกMDPI](https://www.mdpi.com/2077-0383/14/10/3284?utm_source=chatgpt.com)
3. Enhancing Sexual Desire & Brain Processing
Clinical trials show that kissp administration enhances sexual brain processing and arousal in men and women with hypoactive sexual desire disorder (HSDD), with positive effects observed via MRI studies.
Imperial College study summary [oai_citation:5โกImperial College London]
Kiss also modulates emotional and reproductive behaviors, influencing mood, partner preference, and sexual motivation.
Journal of Endocrinology 2018 [oai_citation:6โกjoe.bioscientifica.com](https://joe.bioscientifica.com/view/journals/joe/239/1/JOE-18-0269.xml?utm_source=chatgpt.com)
4. Mood, Behavior & Metabolic Signals
Beyond fertility, kissp-10mg impacts mood and behavior. For instance, kissp-10 exhibits antidepressant-like effects in male rat models, mediated via adrenergic and serotonergic pathways.
PubMed 39605118 [oai_citation:7โกPubMed](https://pubmed.ncbi.nlm.nih.gov/39605118/?utm_source=chatgpt.com)
In cell studies, kissp 10 alters expression of neuropeptide Y (NPY) and BDNF, and affects dopamine and serotonin markersโsuggesting roles in appetite and mood regulation.
PubMed 30477219 [oai_citation:8โกPubMed](https://pubmed.ncbi.nlm.nih.gov/30477219/?utm_source=chatgpt.com)
Summary Table of KISSPEP RESEARCH
| Benefit | Kissp10 Effects |
|---|---|
| Reproductive Hormones | Stimulates GnRH โ LH/FSH; critical in puberty, fertility |
| Therapeutic Applications | Induces ovulation; potential fertility treatments |
| Sexual Desire | Improves arousal and brain responsiveness in HSDD |
| Mood & Behavior | Exhibits antidepressant-like actions; modulates appetite/mood circuits |
References
- PubMed 20672907
- PubMed 15500545
- PubMed 33196464
- MDPI 2025 review
- Imperial College findings
- Journal of Endocrinology 2018
- PubMed 39605118
- PubMed 30477219
PLEASE NOTE THAT ALL PRODUCTS FEATURED HERE ARE INTENDED EXCLUSIVELY FOR RESEARCH AND DEVELOPMENT PURPOSES. THEY ARE NOT DESIGNED FOR ANY FORM OF HUMAN CONSUMPTION. THESE PRODUCTS HAVE NOT UNDERGONE EVALUATION BY THE U.S. FOOD AND DRUG ADMINISTRATION.
